Tenthorey Lab Publications

For the most up-to-date list of publications, see NCBI.

2025

  • Tenthorey JL, del Banco S, Ramzan I, Klingenberg H, Liu C, Emerman M, Malik HS. (2025). Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations. Cell Genomics 0(0):100818. https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00074-6.
Image by Jossie Tamsil
  • Langley CA, Dietzen PA, Emerman M, Tenthorey JL, Malik HS. (2025). Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes. Proc Natl Acad Sci USA 122(4): e2416811122.

2024

  • Geiger RA, Khera D, Tenthorey JL, Kochs G, Graf L, Emerman M, Malik HS. (2024). Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction. bioRxiv [preprint] DOI: https://doi.org/10.1101/2024.10.10.617484. In press, Science Advances.

2022

  • Tenthorey JL, Emerman M, Malik HS. (2022). Evolutionary landscapes of host-virus arms races. Annu Rev Immunol. 40:271-94.

2020

  • Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS. (2020). Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races. eLife 9:e59988.
  • Duxbury Z, Wang S, MacKenzie CI, Tenthorey JL, Zhang X, Huh SU, Hu L, Hill L, Ngou PM, Ding P, Chen J, Ma Y, Guo H, Castel B, Moschou PN, Bernoux M, Dodds PN, Vance RE, Jones JDG. (2020). Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants. Proc Natl Acad Sci USA 117(31):18832-18839.
  • Tenthorey JL, Chavez RA, Thompson TW, Deets KA, Vance RE, Rauch IR. (2020). NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. J Exp Med 217(7):e20191736.

2019

  • Haloupek N, Grob P, Tenthorey JL, Vance RE, Nogales E. (2019). Cryo-EM studies of the NAIP-NLRC4 inflammasomes. Methods Enzymol 625:177-204.

2017

  • Tenthorey JL*, Haloupek N*, Lopez-Blanco JR, Grob P, Adamson E, Hartenian E, Lind N, Bourgeois NM, Chacon P, Nogales E, Vance RE. (2017). The structural basis of flagellin detection by NAIP5: a strategy to limit pathogen immune evasion. Science 358(6365): 883-93. (*Authors contributed equally; direct mentees; highlighted publication)
  • Rauch I, Deets K, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Phillip NH, Ayres J, Brodsky I, Gronert K, Vance RE. (2017). NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of Caspase-1 and -8. Immunity 46(4):649-659.

2016

  • Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE. (2016). NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med 213(5):657-65.

2015

  • Girard JR, Tenthorey JL, Morgan DO. (2015). An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. J Biol Chem 290(40):24614-25.

2014

  • Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE. (2014). Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Mol Cell 54(1):17-29.